Xiaobo Liu

Research: Develop electrochemical biosensors for rapid real-time detection of ROS/RNS species in biological samples and to 

 differentiate live / death pathogenic bacteria 

-  Design biosensors to study the antibiotics-meditated  oxidative stress-related mechanisms in bacteria

-  Miniaturization and application of the cytochrome c biosensor for real-time in vivo monitoring of superoxide radicals in a mouse

intestine model of ischemia and reperfusion injury 

-  Design and development an implantable electrochemical sensor for measuring nitric oxide (NO) release in embryonic zebrafish 

Publications:

[10]  Differential lethal and sublethal effects in embryionic zebrafish exposed to different sizes of silver nanoparticles

X. Liu, E. Dumitrescu, A. Kumar, D. Austin, D.V. Goia, K.N. Wallace, and S. Andreescu

Environ Pollut., 248, 2019, 627-634

https://doi.org/10.1016/j.envpol.2019.02.085

[9] Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality

N. Takahashi, C.C. Gruber, J.H. Yang, X. Liu, D. Braff, C.N. Yashaswini, S. Bhubhanil, Y. Furuta, S. Andreescu, J.J. Collins and G.C. Walker

PNAS, 114(34), 2017, 9164-9169  

https://doi.org/10.1073/pnas.1707466114 

[8] Europium-Doped Cerium Oxide Nanoparticles Limit ROS Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury

E.O. Gubernatorova, X. Liu, A. Othman, W.T. Muraoka, E.P. Koroleva, A. Tumanov, and S. Andreescu

Adv. Healthc. Mater., 6(14), 2017, 1700176

https://doi.org/10.1002/adhm.201700176 

[7] Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish

E. Dumitrescu, D.P. Karunaratne, M.K. Prochaska, X. Liu, K.N. Wallace, and S. Andreescu

Environ. Pollut., 229, 2017, 439-447

https://doi.org/10.1016/j.envpol.2017.06.016

[6] Biosensors based on modularly designed synthetic peptides for recognition, detection and live/dead differentiation of pathogenic bacteria

X. Liu, M. Marrakchi, D. Xu, H. Dong, and S. Andreescu

    Biosens. Bioelectron., 80, 2016, 9-16

https://doi.org/10.1016/j.bios.2016.01.041

[5] Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor

X. Liu, M. Marrakchi, M. Jahne, S. Rogers, and S. Andreescu

    Free Radic. Biol. Med., 91, 2016, 25-33 

https://doi.org/10.1016/j.freeradbiomed.2015.12.001

[4] Reactivity of nanoceria particles exposed to biologically relevant catechol-containing molecules

G. Bulbul, A. Hayat, X. Liu, and S. Andreescu

    RSC Adv., 6, 2016, 60007-60014

https://doi.org/10.1039/C6RA07279H

[3] Chapter 13 - Electrochemical Biosensors for Real-Time Monitoring of Reactive Oxygen and Nitrogen Species

X. Liu, E. Dumitrescu, and S. Andreescu

in: ACS Symposium Series, vol. 1200, - Oxidative Stress: Diagnostics, Prevention, and Therapy -vol. 2, (Eds. M. Hepel, S. Andreescu),

American Chemical Society, 2015, 301-327

https://pubs.acs.org/doi/abs/10.1021/bk-2015-1200.ch013

[2] Electrochemical methods for nanotoxicity assessment

E.R. Ozel, X. liu, R.S.J. Alkasir, and S. Andreescu

Trends Anal. Chem., 59, 2014, 112-120

https://doi.org/10.1016/j.trac.2014.04.006

[1] Chapter - Oxidative Stress and Antibiotic Resistance in Bacterial Pathogens: State of the Art, Methodologies, and Future Trends

M. Marrakchi, X. Liu, and S. Andreescu

in:  Advances in Experimental Medicine and Biology series, vol. 806 - Advancements of Mass Spectrometry in Biomedical Research, 

(Eds. A. Woods and C. Darie), Springer,  2014, 483-489

https://doi.org/10.1007/978-3-319-06068-2_23