Xiaobo Liu

Thesis: Design and Development of Electrochemical Biosensors for

Real-time Monitoring of Oxidative Stress and Efficient

Bacteria Detection

Research: Develop electrochemical biosensors for rapid real-time detection of ROS/RNS species in biological samples and to

differentiate live / death pathogenic bacteria

- Design biosensors to study the antibiotics-meditated oxidative stress-related mechanisms in bacteria

- Miniaturization and application of the cytochrome c biosensor for real-time in vivo monitoring of superoxide radicals in a mouse

intestine model of ischemia and reperfusion injury

- Design and development an implantable electrochemical sensor for measuring nitric oxide (NO) release in embryonic zebrafish

Awards and honors:

  • Graduate travel award to attend the 6th Annual Electrochemical Society (ECS) student chapter symposium, Montreal, Canada - June 10, 2016

  • Best overall poster (3rd place), at the CAMP Annual Technical Meeting, Canandaigua, NY, May 19, 2016

  • Best graduate student poster presentation, at the 3rd Clarkson University Arts & Sciences Graduate Student Symposium, 2016

  • Dr. Ada E. Yonath graduate student travel award, Clarkson University, November 30, 2015

  • Best poster with sustainability application, at The 2nd Graduate Research Symposium, Clarkson University, September 29, 2015

  • Best overall poster (2nd place), CAMP Annual Technical Meeting, Canandaigua, NY, May 21, 2015

  • Best graduate student poster presentation, the 6th Annual ACS - Northern New York Research Symposium, SUNY Potsdam, March 28, 2015

  • Best graduate presentation (2nd place), the ACS - Northern New York Research Symposium, SUNY Plattsburgh, May, 2014

  • Best graduate student poster presentation (2nd place), the 5th ACS Northern New York Annual Research Symposium, 2014

Publications:

[10] Differential lethal and sublethal effects in embryionic zebrafish exposed to different sizes of silver nanoparticles

X. Liu, E. Dumitrescu, A. Kumar, D. Austin, D.V. Goia, K.N. Wallace, and S. Andreescu

Environ Pollut., 248, 2019, 627-634

https://doi.org/10.1016/j.envpol.2019.02.085

[9] Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality

N. Takahashi, C.C. Gruber, J.H. Yang, X. Liu, D. Braff, C.N. Yashaswini, S. Bhubhanil, Y. Furuta, S. Andreescu, J.J. Collins and G.C. Walker

PNAS, 114(34), 2017, 9164-9169

https://doi.org/10.1073/pnas.1707466114

[8] Europium-Doped Cerium Oxide Nanoparticles Limit ROS Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury

E.O. Gubernatorova, X. Liu, A. Othman, W.T. Muraoka, E.P. Koroleva, A. Tumanov, and S. Andreescu

Adv. Healthc. Mater., 6(14), 2017, 1700176

https://doi.org/10.1002/adhm.201700176

[7] Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish

E. Dumitrescu, D.P. Karunaratne, M.K. Prochaska, X. Liu, K.N. Wallace, and S. Andreescu

Environ. Pollut., 229, 2017, 439-447

https://doi.org/10.1016/j.envpol.2017.06.016

[6] Biosensors based on modularly designed synthetic peptides for recognition, detection and live/dead differentiation of pathogenic bacteria

X. Liu, M. Marrakchi, D. Xu, H. Dong, and S. Andreescu

Biosens. Bioelectron., 80, 2016, 9-16

https://doi.org/10.1016/j.bios.2016.01.041

[5] Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor

X. Liu, M. Marrakchi, M. Jahne, S. Rogers, and S. Andreescu

Free Radic. Biol. Med., 91, 2016, 25-33

https://doi.org/10.1016/j.freeradbiomed.2015.12.001

[4] Reactivity of nanoceria particles exposed to biologically relevant catechol-containing molecules

G. Bulbul, A. Hayat, X. Liu, and S. Andreescu

RSC Adv., 6, 2016, 60007-60014

https://doi.org/10.1039/C6RA07279H

[3] Chapter 13 - Electrochemical Biosensors for Real-Time Monitoring of Reactive Oxygen and Nitrogen Species

X. Liu, E. Dumitrescu, and S. Andreescu

in: ACS Symposium Series, vol. 1200, - Oxidative Stress: Diagnostics, Prevention, and Therapy -vol. 2, (Eds. M. Hepel, S. Andreescu),

American Chemical Society, 2015, 301-327

https://pubs.acs.org/doi/abs/10.1021/bk-2015-1200.ch013

[2] Electrochemical methods for nanotoxicity assessment

E.R. Ozel, X. liu, R.S.J. Alkasir, and S. Andreescu

Trends Anal. Chem., 59, 2014, 112-120

https://doi.org/10.1016/j.trac.2014.04.006

[1] Chapter - Oxidative Stress and Antibiotic Resistance in Bacterial Pathogens: State of the Art, Methodologies, and Future Trends

M. Marrakchi, X. Liu, and S. Andreescu

in: Advances in Experimental Medicine and Biology series, vol. 806 - Advancements of Mass Spectrometry in Biomedical Research,

(Eds. A. Woods and C. Darie), Springer, 2014, 483-489

https://doi.org/10.1007/978-3-319-06068-2_23

Conferences:

  • Oral presentations:

- "Comprehensive investigation of potential adverse effects of silver nanoparticle and its environmental transformation in embryonic zebrafish using

implantable biosensor", The 253rd ACS National Meeting, San Francisco, CA, April 6, 2017

- "Quantitative assessment of potential adverse effects from silver nanoparticles exposure in embryonic zebrafish"

The 6th Annual ECS student chapter Symposium, McGill University, Montreal, June 10, 2016

- "Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor"

PITTCON, Atlanta, GA, March 6, 2016

- "Quantitative assessment of nanoparticles exposure potential effects in embryonic zebrafish"

PITTCON, Atlanta, GA, March 6, 2016

- "Assessment of silver nanotoxicity in embryonic zebrafish"

The New England Graduate Student Water Symposium, University of Massachusetts, Amherst, MA, September 13, 2015

- "Design and development of an antimicrobial peptides sensor for bacteria detection"

PITTCON, New Orleans, March 9, 2015

  • Meetings with poster presentations:

- The ACS Northeast Region Meeting (NERM), Binghamton, NY, October 8, 2016

- The 7th Annual ACS Northern New York Section Research Symposium, Clarkson University, March 26, 2016

- Eastern Analytical Symposium (EAS), Somerset, NJ, November 15, 2015

- The 6th Annual ACS Northern New York Section Symposium, SUNY Potsdam, March 28, 2015

- PITTCON, New Orleans, March 9, 2015

- The 5th Annual ACS Northern New York Symposium, SUNY Plattsburgh, April 26, 2014

Department seminar: August 28, 2015

Poster session: PITTCON, Atlanta, GA, March 6, 2016

Best Poster Award at 3rd Arts & Science Graduate Student Symposium, CU, November 17, 2016

Thesis defense: April 12, 2017

Congratulation Dr. Liu !

Commencement day: May 10, 2017

Commencement day: May 10, 2017