Xiaobo Liu
Thesis: Design and Development of Electrochemical Biosensors for
Real-time Monitoring of Oxidative Stress and Efficient
Bacteria Detection
Research: Develop electrochemical biosensors for rapid real-time detection of ROS/RNS species in biological samples and to
differentiate live / death pathogenic bacteria
- Design biosensors to study the antibiotics-meditated oxidative stress-related mechanisms in bacteria
- Miniaturization and application of the cytochrome c biosensor for real-time in vivo monitoring of superoxide radicals in a mouse
intestine model of ischemia and reperfusion injury
- Design and development an implantable electrochemical sensor for measuring nitric oxide (NO) release in embryonic zebrafish
Awards and honors:
Graduate travel award to attend the 6th Annual Electrochemical Society (ECS) student chapter symposium, Montreal, Canada - June 10, 2016
Best overall poster (3rd place), at the CAMP Annual Technical Meeting, Canandaigua, NY, May 19, 2016
Best graduate student poster presentation, at the 3rd Clarkson University Arts & Sciences Graduate Student Symposium, 2016
Dr. Ada E. Yonath graduate student travel award, Clarkson University, November 30, 2015
Best poster with sustainability application, at The 2nd Graduate Research Symposium, Clarkson University, September 29, 2015
Best overall poster (2nd place), CAMP Annual Technical Meeting, Canandaigua, NY, May 21, 2015
Best graduate student poster presentation, the 6th Annual ACS - Northern New York Research Symposium, SUNY Potsdam, March 28, 2015
Best graduate presentation (2nd place), the ACS - Northern New York Research Symposium, SUNY Plattsburgh, May, 2014
Best graduate student poster presentation (2nd place), the 5th ACS Northern New York Annual Research Symposium, 2014
Publications:
[10] Differential lethal and sublethal effects in embryionic zebrafish exposed to different sizes of silver nanoparticles
X. Liu, E. Dumitrescu, A. Kumar, D. Austin, D.V. Goia, K.N. Wallace, and S. Andreescu
Environ Pollut., 248, 2019, 627-634
https://doi.org/10.1016/j.envpol.2019.02.085
[9] Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality
N. Takahashi, C.C. Gruber, J.H. Yang, X. Liu, D. Braff, C.N. Yashaswini, S. Bhubhanil, Y. Furuta, S. Andreescu, J.J. Collins and G.C. Walker
PNAS, 114(34), 2017, 9164-9169
https://doi.org/10.1073/pnas.1707466114
[8] Europium-Doped Cerium Oxide Nanoparticles Limit ROS Formation and Ameliorate Intestinal Ischemia-Reperfusion Injury
E.O. Gubernatorova, X. Liu, A. Othman, W.T. Muraoka, E.P. Koroleva, A. Tumanov, and S. Andreescu
Adv. Healthc. Mater., 6(14), 2017, 1700176
https://doi.org/10.1002/adhm.201700176
[7] Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish
E. Dumitrescu, D.P. Karunaratne, M.K. Prochaska, X. Liu, K.N. Wallace, and S. Andreescu
Environ. Pollut., 229, 2017, 439-447
https://doi.org/10.1016/j.envpol.2017.06.016
[6] Biosensors based on modularly designed synthetic peptides for recognition, detection and live/dead differentiation of pathogenic bacteria
X. Liu, M. Marrakchi, D. Xu, H. Dong, and S. Andreescu
Biosens. Bioelectron., 80, 2016, 9-16
https://doi.org/10.1016/j.bios.2016.01.041
[5] Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor
X. Liu, M. Marrakchi, M. Jahne, S. Rogers, and S. Andreescu
Free Radic. Biol. Med., 91, 2016, 25-33
https://doi.org/10.1016/j.freeradbiomed.2015.12.001
[4] Reactivity of nanoceria particles exposed to biologically relevant catechol-containing molecules
G. Bulbul, A. Hayat, X. Liu, and S. Andreescu
RSC Adv., 6, 2016, 60007-60014
https://doi.org/10.1039/C6RA07279H
[3] Chapter 13 - Electrochemical Biosensors for Real-Time Monitoring of Reactive Oxygen and Nitrogen Species
X. Liu, E. Dumitrescu, and S. Andreescu
in: ACS Symposium Series, vol. 1200, - Oxidative Stress: Diagnostics, Prevention, and Therapy -vol. 2, (Eds. M. Hepel, S. Andreescu),
American Chemical Society, 2015, 301-327
https://pubs.acs.org/doi/abs/10.1021/bk-2015-1200.ch013
[2] Electrochemical methods for nanotoxicity assessment
E.R. Ozel, X. liu, R.S.J. Alkasir, and S. Andreescu
Trends Anal. Chem., 59, 2014, 112-120
https://doi.org/10.1016/j.trac.2014.04.006
[1] Chapter - Oxidative Stress and Antibiotic Resistance in Bacterial Pathogens: State of the Art, Methodologies, and Future Trends
M. Marrakchi, X. Liu, and S. Andreescu
in: Advances in Experimental Medicine and Biology series, vol. 806 - Advancements of Mass Spectrometry in Biomedical Research,
(Eds. A. Woods and C. Darie), Springer, 2014, 483-489
Conferences:
Oral presentations:
- "Comprehensive investigation of potential adverse effects of silver nanoparticle and its environmental transformation in embryonic zebrafish using
implantable biosensor", The 253rd ACS National Meeting, San Francisco, CA, April 6, 2017
- "Quantitative assessment of potential adverse effects from silver nanoparticles exposure in embryonic zebrafish"
The 6th Annual ECS student chapter Symposium, McGill University, Montreal, June 10, 2016
- "Real-time investigation of antibiotics-induced oxidative stress and superoxide release in bacteria using an electrochemical biosensor"
PITTCON, Atlanta, GA, March 6, 2016
- "Quantitative assessment of nanoparticles exposure potential effects in embryonic zebrafish"
PITTCON, Atlanta, GA, March 6, 2016
- "Assessment of silver nanotoxicity in embryonic zebrafish"
The New England Graduate Student Water Symposium, University of Massachusetts, Amherst, MA, September 13, 2015
- "Design and development of an antimicrobial peptides sensor for bacteria detection"
PITTCON, New Orleans, March 9, 2015
Meetings with poster presentations:
- The ACS Northeast Region Meeting (NERM), Binghamton, NY, October 8, 2016
- The 7th Annual ACS Northern New York Section Research Symposium, Clarkson University, March 26, 2016
- Eastern Analytical Symposium (EAS), Somerset, NJ, November 15, 2015
- The 6th Annual ACS Northern New York Section Symposium, SUNY Potsdam, March 28, 2015
- PITTCON, New Orleans, March 9, 2015
- The 5th Annual ACS Northern New York Symposium, SUNY Plattsburgh, April 26, 2014
Department seminar: August 28, 2015
Poster session: PITTCON, Atlanta, GA, March 6, 2016
Best Poster Award at 3rd Arts & Science Graduate Student Symposium, CU, November 17, 2016
Thesis defense: April 12, 2017
Committee: Profs: Silvana Andreescu, Artem Melman, Kenneth Wallace, He Dong, Shane Rogers
Congratulation Dr. Liu !
Commencement day: May 10, 2017
