Malli Ganesana

Thesis: Electrochemical Biosensors for Real-time

Environmental and Clinical Monitoring

Research: Developing electrochemical method and biosensors to evaluate the superoxide radical mobility at the extracellular space in a brain slice model and environmental pollutants (pesticides, bisphenol A)

- Monitor in vitro and in vivo the nanoparticles-induced toxicity and oxidative stress using biomedical sensors, specifically the temporal

release of superoxide in a brain slice model of hypoxia using cytochrome c biosensor

- Developing robust, practical biosensors for monitoring clinical and environmental samples

- Implementation of different immobilization methods (affinity, Self-Assembled Monolayer - SAM) in biosensors development

Awards and honors:

  • Research intern fellow - Bayer Healthcare Pharmaceuticals (Global Biologics and Analytical Development Division), June - August, 2011

Publications:

[8] Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments

R.E. Ozel, C.R. Ispas, M. Ganesana, J.C. Leiter, and S. Andreescu

Biosens. Bioelectron., 52, 2014, 397-402

https://doi.org/10.1016/j.bios.2013.08.054

[7] Real-time monitoring of superoxide accumulation and antioxidant activity in a brain slice model using an electrochemical cyt c biosensor

M. Ganesana, J.S. Erlichman, and S. Andreescu

Free Radic. Biol. Med., 53, 2012, 2240-2249

https://doi.org/10.1016/j.freeradbiomed.2012.10.540

[6] Site-specific immobilization of a (His)6-tagged acetylcholinesterase on nickel nanoparticles for highly sensitive toxicity biosensors

M. Ganesana, G. Istambouille, J.-L. Marty, T. Noguer, and S. Andreescu

Biosens. Bioelectron., 30, 2011, 43-48

https://doi.org/10.1016/j.bios.2011.08.024

[5] Enzyme functionalized nanoparticles for electrochemical biosensors: A comparative study with applications for the detection of

bisphenol A

R.S.J. Alkasir, M. Ganesana, Y.-H. Won, L. Stanciu, and S. Andreescu

Biosens, Bioelectron., 26, 2010, 43-49

https://doi.org/10.1016/j.bios.2010.05.001

[4] AChE Biosensor based on zinc oxide sol-gel for the detection of pesticides

R. Sinha, M. Ganesana, S. Andreescu and L. Stanciu

Anal. Chim. Acta, 661(2), 2010, 195-199

https://doi.org/10.1016/j.aca.2009.12.020

[3] Biomagnetic glasses: preparation, characterization and biosensor applications

Y.-H. Won, H.S. Jang, S.M. Kim, M. Ganesana, E. Stach, S. Andreescu and L.A. Stanciu

Langmuir, 26(6), 2010, 4320-4326

https://doi.org/10.1021/la903422q


[2] Chapter - Biosensors, Toxicity Monitoring

M. Ornatska, M. Ganesana, and S. Andreescu

in Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, Ed. M.S. Flickinger, Wiley, 2009

https://doi.org/10.1002/9780470054581.eib163

[1] Magnetic Particles-Based Hybrid Platforms for Bioanalytical Sensors

L. Stanciu, Y.-H. Won, M. Ganesana, and S. Andreescu

Sensors, 9(4), 2009, 2976-2999

https://doi.org/10.3390/s90402976

Conferences:

  • Oral presentations:

- "Chitosan Based Electrochemical Microsensors for In vivo Detection of Serotonin in Zebrafish Embryos"

PITTCON, Orlando, FL, March 11-15, 2012

- “Implantable sensors for in vivo measurement of neurological activity and nanoparticle-induced toxicity”

The 37th ACS-Northeast Regional Meeting (NERM), SUNY Potsdam, Potsdam, NY, June 2-5, 2010

  • Meetings with poster presentations:

- PITTCON, Orlando, FL, March 10-16, 2012

- The 238th ACS national meeting, Washington, DC, August 16-20, 2009

March 2012 - Pittcon, Orlando, FL

May 11 -Commencement day, Congratulation Malli !