Thesis: Electrochemical Biosensors for Real-time
Environmental and Clinical Monitoring
Research: Developing electrochemical method and biosensors to evaluate the superoxide radical mobility at the extracellular space in a brain slice model and environmental pollutants (pesticides, bisphenol A)
- Monitor in vitro and in vivo the nanoparticles-induced toxicity and oxidative stress using biomedical sensors, specifically the temporal
release of superoxide in a brain slice model of hypoxia using cytochrome c biosensor
- Developing robust, practical biosensors for monitoring clinical and environmental samples
- Implementation of different immobilization methods (affinity, Self-Assembled Monolayer - SAM) in biosensors development
Awards and honors:
Research intern fellow - Bayer Healthcare Pharmaceuticals (Global Biologics and Analytical Development Division), June - August, 2011
Publications:
[8] Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments
R.E. Ozel, C.R. Ispas, M. Ganesana, J.C. Leiter, and S. Andreescu
Biosens. Bioelectron., 52, 2014, 397-402
https://doi.org/10.1016/j.bios.2013.08.054
[7] Real-time monitoring of superoxide accumulation and antioxidant activity in a brain slice model using an electrochemical cyt c biosensor
M. Ganesana, J.S. Erlichman, and S. Andreescu
Free Radic. Biol. Med., 53, 2012, 2240-2249
https://doi.org/10.1016/j.freeradbiomed.2012.10.540
[6] Site-specific immobilization of a (His)6-tagged acetylcholinesterase on nickel nanoparticles for highly sensitive toxicity biosensors
M. Ganesana, G. Istambouille, J.-L. Marty, T. Noguer, and S. Andreescu
Biosens. Bioelectron., 30, 2011, 43-48
https://doi.org/10.1016/j.bios.2011.08.024
[5] Enzyme functionalized nanoparticles for electrochemical biosensors: A comparative study with applications for the detection of
bisphenol A
R.S.J. Alkasir, M. Ganesana, Y.-H. Won, L. Stanciu, and S. Andreescu
Biosens, Bioelectron., 26, 2010, 43-49
https://doi.org/10.1016/j.bios.2010.05.001
[4] AChE Biosensor based on zinc oxide sol-gel for the detection of pesticides
R. Sinha, M. Ganesana, S. Andreescu and L. Stanciu
Anal. Chim. Acta, 661(2), 2010, 195-199
https://doi.org/10.1016/j.aca.2009.12.020
[3] Biomagnetic glasses: preparation, characterization and biosensor applications
Y.-H. Won, H.S. Jang, S.M. Kim, M. Ganesana, E. Stach, S. Andreescu and L.A. Stanciu
Langmuir, 26(6), 2010, 4320-4326
https://doi.org/10.1021/la903422q
[2] Chapter - Biosensors, Toxicity Monitoring
M. Ornatska, M. Ganesana, and S. Andreescu
in Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, Ed. M.S. Flickinger, Wiley, 2009
https://doi.org/10.1002/9780470054581.eib163
[1] Magnetic Particles-Based Hybrid Platforms for Bioanalytical Sensors
L. Stanciu, Y.-H. Won, M. Ganesana, and S. Andreescu
Sensors, 9(4), 2009, 2976-2999
Conferences:
Oral presentations:
- "Chitosan Based Electrochemical Microsensors for In vivo Detection of Serotonin in Zebrafish Embryos"
PITTCON, Orlando, FL, March 11-15, 2012
- “Implantable sensors for in vivo measurement of neurological activity and nanoparticle-induced toxicity”
The 37th ACS-Northeast Regional Meeting (NERM), SUNY Potsdam, Potsdam, NY, June 2-5, 2010
Meetings with poster presentations:
- PITTCON, Orlando, FL, March 10-16, 2012
- The 238th ACS national meeting, Washington, DC, August 16-20, 2009
March 2012 - Pittcon, Orlando, FL
May 11 -Commencement day, Congratulation Malli !
Thesis defense: June 11, 2012
Committee: Profs: Silvana Andreescu, Evgeny Katz, Kenneth Wallace, Costel Darie, Devon Shipp, Joseph Erlichman
Congratulation Dr. Ganesana !